309 research outputs found

    On differential equation on four-point correlation function in the Conformal Toda Field Theory

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    The properties of completely degenerate fields in the Conformal Toda Field Theory are studied. It is shown that a generic four-point correlation function that contains only one such field does not satisfy ordinary differential equation in contrast to the Liouville Field Theory. Some additional assumptions for other fields are required. Under these assumptions we write such a differential equation and solve it explicitly. We use the fusion properties of the operator algebra to derive a special set of three-point correlation function. The result agrees with the semiclassical calculations.Comment: 5 page

    Validating the Assessing Student Competence and Knowledge of Social Determinants of Health (ASCK-SDH) Instrument

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    The impact of the social determinants of health (SDH) on health outcomes is receiving increased attention. Health profession students need to learn about SDH; however, there are no validated tools to measure student competence in assessing SDH. There is a need for a brief, valid instrument to measure student competency and knowledge of SDH. This study is a secondary analysis of data collected pre (N=394) and post (N=387) for an interprofessional learning event. We utilized principal component analysis (PCA) with varimax rotation to determine the internal structure of the tool. The original measure consisted of 11 items; the analysis resulted in two factors. Based on the two factors it was determined the three items from Factor 2 were not contributing to the scale; therefore, they were removed. The final measure, Assessing Student Competence & Knowledge of Social Determinants of Health (ASCK-SDH), consists of eight items rated on a 4-point Likert scale. The measure indicated high internal consistency at pre (Cronbach’s α= 0.81) and post (Cronbach’s α=0.89) tests. The ASCK-SDH tool provides a valid instrument to measure student competence and knowledge about SDH and can be used to assess learning

    Validating the Assessing Student Competence and Knowledge of Social Determinants of Health (ASCK-SDH) Instrument

    Get PDF
    The impact of the social determinants of health (SDH) on health outcomes is receiving increased attention. Health profession students need to learn about SDH; however, there are no validated tools to measure student competence in assessing SDH. There is a need for a brief, valid instrument to measure student competency and knowledge of SDH. This study is a secondary analysis of data collected pre (N=394) and post (N=387) for an interprofessional learning event. We utilized principal component analysis (PCA) with varimax rotation to determine the internal structure of the tool. The original measure consisted of 11 items; the analysis resulted in two factors. Based on the two factors it was determined the three items from Factor 2 were not contributing to the scale; therefore, they were removed. The final measure, Assessing Student Competence & Knowledge of Social Determinants of Health (ASCK-SDH), consists of eight items rated on a 4-point Likert scale. The measure indicated high internal consistency at pre (Cronbach’s α= 0.81) and post (Cronbach’s α=0.89) tests. The ASCK-SDH tool provides a valid instrument to measure student competence and knowledge about SDH and can be used to assess learning

    The Crowd in Requirements Engineering: The Landscape and Challenges

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    Crowd-based requirements engineering (CrowdRE) could significantly change RE. Performing RE activities such as elicitation with the crowd of stakeholders turns RE into a participatory effort, leads to more accurate requirements, and ultimately boosts software quality. Although any stakeholder in the crowd can contribute, CrowdRE emphasizes one stakeholder group whose role is often trivialized: users. CrowdRE empowers the management of requirements, such as their prioritization and segmentation, in a dynamic, evolved style through collecting and harnessing a continuous flow of user feedback and monitoring data on the usage context. To analyze the large amount of data obtained from the crowd, automated approaches are key. This article presents current research topics in CrowdRE; discusses the benefits, challenges, and lessons learned from projects and experiments; and assesses how to apply the methods and tools in industrial contexts. This article is part of a special issue on Crowdsourcing for Software Engineering

    Survival probability of mutually killing Brownian motions and the O'Connell process

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    Recently O'Connell introduced an interacting diffusive particle system in order to study a directed polymer model in 1+1 dimensions. The infinitesimal generator of the process is a harmonic transform of the quantum Toda-lattice Hamiltonian by the Whittaker function. As a physical interpretation of this construction, we show that the O'Connell process without drift is realized as a system of mutually killing Brownian motions conditioned that all particles survive forever. When the characteristic length of interaction killing other particles goes to zero, the process is reduced to the noncolliding Brownian motion (the Dyson model).Comment: v2: AMS-LaTeX, 20 pages, 2 figures, minor corrections made for publication in J. Stat. Phy

    Interaction of eukaryotic translation initiation factor 4G with the nuclear cap-binding complex provides a link between nuclear and cytoplasmic functions of the m7 guanosine cap

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    In eukaryotes the majority of mRNAs have an m7G cap that is added cotranscriptionally and that plays an important role in many aspects of mRNA metabolism. The nuclear cap-binding complex (CBC; consisting of CBP20 and CBP80) mediates the stimulatory functions of the cap in pre-mRNA splicing, 3' end formation, and U snRNA export. As little is known about how nuclear CBC mediates the effects of the cap in higher eukaryotes, we have characterized proteins that interact with CBC in HeLa cell nuclear extracts as potential mediators of its function. Using cross-linking and coimmunoprecipitation, we show that eukaryotic translation initiation factor 4G (eIF4G), in addition to its function in the cytoplasm, is a nuclear CBC-interacting protein. We demonstrate that eIF4G interacts with CBC in vitro and that, in addition to its cytoplasmic localization, there is a significant nuclear pool of eIF4G in mammalian cells in vivo. Immunoprecipitation experiments suggest that, in contrast to the cytoplasmic pool, much of the nuclear eIF4G is not associated with eIF4E (translation cap binding protein of eIF4F) but is associated with CBC. While eIF4G stably associates with spliceosomes in vitro and shows close association with spliceosomal snRNPs and splicing factors in vivo, depletion studies show that it does not participate directly in the splicing reaction. Taken together the data indicate that nuclear eIF4G may be recruited to pre-mRNAs via its interaction with CBC and accompanies the mRNA to the cytoplasm, facilitating the switching of CBC for eIF4F. This may provide a mechanism to couple nuclear and cytoplasmic functions of the mRNA cap structure
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